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    Association details:
    Biomarker:EGFR 181946 C>T
    Cancer:Non Small Cell Lung Cancer
    Drug:gefitinib (EGFR inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    New
    Source:
    Drug Resist Updat
    Title:

    Clinical implications of germline variations for treatment outcome and drug resistance for small molecule kinase inhibitors in patients with non-small cell lung cancer

    Published date:
    04/05/2022
    Excerpt:
    The polymorphism 181946 C>T in the EGFR gene has also been investigated for gefitinib treatment....Two of three studies did find significant decreases in PFS and OS...
    DOI:
    https://doi.org/10.1016/j.drup.2022.100832